Research summary, systematic review or meta-analysis, 2025

Systematic review on radiation-induced DNA damage and cancer risk in endovascular operators

Maris EL, Klaassen J, Hazenberg CEVB, Petri BJ, Trimarchi S, van Herwaarden JA. Journal of vascular surgery. 2025

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In plain language

A review of 25 studies suggests that vascular surgeons, interventional cardiologists and radiologists may show more DNA damage and a higher risk of some cancers, such as leukemia, thyroid, skin and brain. The evidence is mostly observational and does not prove cause.

At a glance

Type of study
Systematic review or meta-analysis, Systematic review
Who was studied
Vascular surgeons, Interventional cardiologists, Interventional radiologists
Size
n = 25 studies
Summary based on
the abstract

What it found

  • Occupational exposure in endovascular operators may cause early-stage DNA damage shortly after exposure.

  • Chronic DNA damage, including double-strand breaks and chromosomal aberrations, was observed and hypothesized to contribute to genomic instability and carcinogenesis.

  • Studies suggest increased cancer risk, notably leukemia, thyroid cancer, and cancers of unprotected areas such as skin and brain.

  • Twenty-five studies from 2000 to April 2025 met inclusion criteria.

    Key figures: 25 studies

Limits to keep in mind

The abstract reports no pooled estimates, and the included studies mix experimental, observational and case report designs. Findings are framed as suggestive, and the risk-of-bias results are not given.

How this summary was made

ORSIF prepared this summary with AI assistance from the abstract of the paper. A program then checked that the passage supporting each finding appears word for word in that source. A person has not yet reviewed each summary, so read the original before relying on a number. ORSIF summarizes research and does not endorse any product or company. Report a problem with this summary.

Prepared November 3, 2026.