In plain language
In pregnant mice given single X-ray doses, offspring had raised mitochondrial DNA copy number from 0.2 Gy and mothers showed changes at higher doses. These are animal biomarker findings at high doses, not evidence of health effects in pregnant fluoroscopy staff.
At a glance
- Type of study
- Original research, Laboratory or biomarker study
- Summary based on
- the abstract
What it found
Offspring exposed in utero showed significantly raised mtDNA copy number at doses of 0.2 Gy and above, with intact mtDNA ratio unchanged.
Key figures: ≥ 0.2 Gy
In mothers, mtDNA copy number rose at 2 Gy and the intact mtDNA ratio fell at 0.5 Gy and above.
Key figures: mtDNAcn increase at 2 Gy; intact ratio decrease at ≥ 0.5 Gy
Live offspring were obtained only at gestational day 8 doses of 0.5 Gy or lower.
Key figures: ≤ 0.5 Gy
Offspring sex ratio and body weight did not differ between control and irradiated groups.
Limits to keep in mind
Mouse study with single acute X-ray doses (0.05 to 2 Gy) far above typical occupational exposures; group sizes not reported in the abstract and functional health consequences were not measured.
Related research summaries
- Male reproductive impairment linked to occupational ionizing radiation exposure in radiology workers (2026, Case-control study)
- Occupational Protection in Interventional Radiology. A Joint Guideline of the Cardiovascular and Interventional Radiological Society of Europe and the Society of Interventional Radiology (2026, Guideline or consensus statement)
- Radiation exposure in interventional cardiology: a narrative review of health effects and novel approaches to ensure radiation safety (2025, Narrative review)
- Occupational Risks of Radiation Exposure to Cardiologists (2024, Narrative review)
- Practical guidance to reduce radiation exposure in electrophysiology applying ultra low-dose protocols: a European Heart Rhythm Association review (2023, Narrative review)
How this summary was made
ORSIF prepared this summary with AI assistance from the abstract of the paper. A program then checked that the passage supporting each finding appears word for word in that source. A person has not yet reviewed each summary, so read the original before relying on a number. ORSIF summarizes research and does not endorse any product or company. Report a problem with this summary.
Prepared November 3, 2026.