Rola R, Otsuka S, Obenaus A, et al. Indicators Of Hippocampal Neurogenesis Are Altered By56fe-Particle Irradiation In A Dose-Dependent Manner. Radiat Res. 2004 Oct;162(4):442-446.

The health risks to astronauts exposed to high-LET radiation include possible cognitive deficits. The pathogenesis of radiation-induced cognitive injury is unknown but may involve loss of neural precursor cells from the subgranular zone (SGZ) of the hippocampal dentate gyrus. To address this hypothesis, adult female C57BL/6 mice received whole-body irradiation with a 1 GeV/nucleon iron-particle beam in a single fraction of 0, 1, 2 and 3 Gy. The present data provide the first evidence that high-LET radiation has deleterious effects on cells associated with hippocampal neurogenesis.

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